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Pragmatic trials are those that are designed to inform the practice of clinical trials in real life. They are typically described by their focus on practical aspects of designing a study which include recruitment and consent, adherence and the use of standard equipment.

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A pragmatic study that involves a variety investigators and includes participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This type of heterogeneity, which is essential for a pragmatic trial to be valid and reduce bias in results, is also necessary. However, too much heterogeneity could cause issues with the design of the trial.

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The aim of pragmatic trials is to mimic real-life scenarios and to achieve maximum validity externally. They are usually commissioned by policymakers and practitioners to inform their decisions. They can also be used to determine the cause-effect relationship of an intervention and its results. However, they should not, be used to replace explanatory studies.

The concept of pragmatism is controversial and there are doubts about whether pragmatic trials should be used to replace explanation tests or if they should serve as an addition to them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which confirm the validity of a clinical or physiological hypothesis, and pragmatic trials, which guide policy and practice decisions. They also suggested the framework for pragmatic trials, which they called PRECIS.2 This tool attempted to define the elements of a pragmatic study that include the recruitment process, 프라그마틱 the design and 프라그마틱 플레이 delivery of the intervention, and the follow-up.

There is a positive increase in the number of pragmatic trials published. A recent Medline query that used the words pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs) returned 34 articles. These are shown in red on Figure 2. This indicates that the health science community is becoming more acquaint to the issue of pragmatic thinking. However, it is important to remember that the majority of these studies were conducted in primary care settings.