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Clinical trials that are designed to help inform practice in the real world are called pragmatic trials. They are often described as a focus on the practical aspects of designing a study, including the recruitment process and consent, adhering and the use routinely available equipment.

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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which utilized various investigators and participants from different geographical regions. This kind of heterogeneity is required for practical trials to be valid, and it also reduces the chance of bias in the results. However, too much heterogeneity can result in problems with the design of the trial.

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Pragmatic trials aim to mimic real-life settings and achieve maximum external validity. They are typically commissioned by policy makers and practitioners to inform their decision making. They can also be used to assess the causal relationship between an intervention and its results. However, they should not be used to replace explanatory studies.

The concept of pragmatism is controversial and 프라그마틱 무료체험 메타 프라그마틱 슬롯 추천버프 (please click the following page) there are concerns about whether pragmatic trials should replace tests for explanations or if they should be an addition to them. Schwartz and Lellouch1 proposed the distinction between explanation studies, which confirm a physiological hypothesis or clinical hypothesis, as well as pragmatic trials, which inform the decision-making process for policy and practice. They also suggested a framework dubbed PRECIS for pragmatic trials.2 This tool tried to define the elements of a pragmatic study that includes the recruitment, design, and delivery of the intervention and follow-up.

There is a growing increase in the number of pragmatic trials that are published. A recent Medline query using the keywords pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs) returned 34 articles. These are highlighted in red on Figure 2. This is an indication that the health sciences community is becoming more acquaint to the issue of pragmatism. It is important to note that the majority were conducted in primary-care settings.