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Pragmatic trials are those that are designed to provide information for the real-world practice of clinical. They are often described as a focus on the practical aspects of designing a study which include the recruitment and consent process, as well as adherence and the use of routinely available equipment.

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Pragmatic is a software developer that provides a variety of casino games on online gambling platforms. Its iGaming software is used by top operators and land based casinos. The company provides front-end site design tools, analysis tools and marketing, promotions, security payment systems, customer support and bug-reporting. The company also offers a safe environment with high-quality graphics, gameplay and security.

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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which used various investigators and included participants from different geographical regions. This kind of heterogeneity, which is essential for pragmatic trials to be reliable and to reduce bias in the results is also essential. A high degree of heterogeneity, however, can cause problems with the design of the trial.

Pragmatic Play is also a major player in the live casino market, offering an extensive selection of table games like as Blackjack and Roulette in various versions. The live studios of the company in Romania and Malta offer an authentic gambling experience for players and offer an extensive selection of virtual betting options. The company also has created various interactive games to make online gambling enjoyable. Some of these shows feature live hosts, while others are hosted by famous personalities from the industry.

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In addition to their mobile-friendly slots, Pragmatic Play also offers tables games and live dealer casinos. Pragmatic Play is licensed by several regulatory bodies which include Malta Gaming Authority and UK Gambling Commission. The company's games are secured by top-of-the-line encryption and its security team is on hand to assist players in any situation.

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Pragmatic Play has gained a reputation for offering top-quality games and an outstanding user experience. Its software is designed to work on mobile devices and supports multiple languages. It has earned itself the status of one of the top gaming platforms in the casino industry despite its relative youth. Wolves is one of the latest games which is a five-reel slot machine with a hefty RTP and stunning graphics. The other notable titles include Wolf Gold and Chilli Heat.

The aim of pragmatic trials is to simulate real-life scenarios and to achieve maximum credibility externally. They are usually requested by practitioners and policy makers to inform their decision making. They are also a good method of determining the causality between the intervention and its effects. However, they should not be used to replace the need for explanation studies.

The pragmatism idea is controversial and there are doubts about whether pragmatic trials can replace explanatory tests or if they are an alternative to them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which prove the clinical or physiological hypothesis, and pragmatic trials, which guide policy and practice decisions. They also suggested a framework dubbed PRECIS for pragmatic trials.2 This tool attempted to define the elements of a pragmatic study that includes the recruitment, design, and delivery of the intervention and follow-up.

There is a growing increase in the number pragmatic trials that have been published. A recent Medline query that used the words pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs), returned 34 articles. These are highlighted in red on Figure 2. This indicates that the health sciences community has become more aware of the importance of pragmatism. It is important to note, however, that the majority of these studies were conducted in primary care settings.