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Clinical trials that are designed to help inform practice in the real world are called pragmatic trials. They are usually characterized by a focus on practical aspects of the study design, including the recruitment process and consent in adherence, as well as the use of standard equipment.
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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which used various investigators and included participants from different geographic areas. This type of heterogeneity is essential for practical trials to be valid and reduces bias in the results. Too much heterogeneity, however, can cause problems with the trial design.
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Pragmatic trials aim to mimic real-life situations and attain maximum external validity. They are typically commissioned by policy makers and practitioners to guide their decision-making. They also provide a useful way to identify the cause-effect relationship between an intervention and its outcomes. They should not, however be used to replace the need for explanation studies.
The idea of pragmatism is controversial, and there are questions regarding whether pragmatic trials could replace tests for explanations or if they should serve as an alternative to them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which validate the clinical or physiological hypothesis and 프라그마틱 슬롯 사이트 - pop over to this web-site - pragmatic trials, which inform policy and practice decisions. They also proposed the framework for pragmatic trials, which they called PRECIS.2 This tool was designed to define the elements of a pragmatic trial which includes the recruitment process, the design and delivery of the intervention, as well as monitoring.
There is an encouraging increase in the number pragmatic trials that are published. A recent Medline search using the keywords pragmatic and naturalistic, restricted to controlled trials randomized to control (RCTs) produced 34 articles, which are shown in red in Figure 2. This suggests that the health sciences community is becoming more aware of the importance of pragmatic thinking. It is important to remember that the majority of these trials were conducted in primary care settings.