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Pragmatic trials are studies designed to provide information for the real-world practice of clinical. They are often characterized as a focus on the practical aspects of design, including recruitment and consent, adherence and the use of standard equipment.
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Pragmatic, a software company provides a variety of casino games to online gambling platforms. Pragmatic's iGaming software is used by the top operators as well as casinos that are located in the land. The company offers front-end design tools, analysis, marketing, promotions, payment systems, security, customer service and bug reporting. In addition, the company provides its players a safe and secure environment with high-quality graphics as well as games.
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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which employed a variety of investigators and participants from different geographical regions. This type of heterogeneity that is crucial for a pragmatic trial to be reliable and lessen the chance of bias is also essential. Too much heterogeneity, however, can cause problems with the design of the trial.
Pragmatic Play Pragmatic Play, a major player on the live casino market, provides a variety of classic table games like Blackjack and Roulette. The live studios of Pragmatic Play in Romania and Malta offer customers an authentic gaming experience as well as a broad variety of betting options via virtual. The company also has created several interactive game shows to make gambling online enjoyable. Some of these shows are broadcast live, while others are hosted by famous personalities from the field.
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The goal of pragmatic trials is to replicate real-life scenarios and gain maximum credibility externally. They are usually requested by policy makers and practitioners to aid in their decision-making. They can also be used to assess the causality of an intervention and its effects. However, they shouldn't be used to substitute for the use of explanation trials.
The concept of pragmatism is controversial and there are concerns about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 made the distinction between explanation studies, which confirm a physiological hypothesis or clinical hypothesis, and pragmatic trials that aid in policy and practice decision-making. They also suggested a framework known as PRECIS for pragmatic trials.2 The tool was designed to define the characteristics of a practical study that includes recruitment, design, implementation of the intervention and its follow-up.
The number of pragmatic trials is growing. A recent Medline search using the words pragmatic and naturalistic, limited to randomised controlled trials (RCTs), returned 34 articles. They are displayed in red on Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatism. It is important to remember that the majority of studies were conducted in primary-care settings.